A SYNERGISTIC TRIAD OF CHEMOTHERAPY, IMMUNE CHECKPOINT INHIBITORS, AND CALORIC RESTRICTION MIMETICS ERADICATES TUMORS IN MICE

A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice

We have recently shown Built-In Coffee Maker that chemotherapy with immunogenic cell death (ICD)-inducing agents can be advantageously combined with fasting regimens or caloric restriction mimetics (CRMs) to achieve superior tumor growth control via a T cell-dependent mechanism.Here, we show that the blockade of the CD11b-dependent extravasation of

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Ozonated Oils as Antimicrobial Systems in Topical Applications. Their Characterization, Current Applications, and Advances in Improved Delivery Techniques

The search for a wide spectrum of antimicrobial agents that can avoid resistance while maintaining reasonable side effects has led to ozonated oils experiencing an increase in scientific interest and clinical applications.The treatment of vegetable oils with ozone leads to the creation of a reservoir of ozone that slowly releases into the skin than

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New Quaternary fossils from high elevation cave deposits in Cuba

High elevation fossil deposits in Cuba have been poorly studied, and there is a boys sweats limited understanding of how altitudinal changes could have affected the composition of faunal communities in the past.Here, we report fossils of 13 vertebrate species and an invertebrate from 11 late Quaternary cave deposits at elevations ranging from 532 t

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